IGHV3OR16-12

Across TCGA patient cohorts, IGHV3OR16-12 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,002 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IGHV3OR16-12-associated GO terms across cancer lineages are B cell receptor signaling pathway, Humoral immune response mediated by circulating immunoglobulin, and Response to protozoan. Each is linked with IGHV3OR16-12 in more than 28 cancer types. Because this analysis shows association rather than direction, both IGHV3OR16-12-to-partner and partner-to-IGHV3OR16-12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, B cell receptor signaling pathway grouped by IGHV3OR16-12-low versus IGHV3OR16-12-high in CHOL.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3OR16-12→partner) and Y-score (partner→IGHV3OR16-12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	B cell receptor signaling pathway →	+0.094	+0.603	<.001	<.001	3	29
THCA	Humoral immune response mediated by circulating immunoglobulin →	+0.164	+0.783	<.001	<.001	3	28
SKCM	Response to protozoan →	+0.070	+0.500	<.001	<.001	3	27
ESCA	B cell mediated immunity →	+0.106	+0.546	<.001	<.001	3	27
THCA	Antimicrobial humoral response →	+0.111	+0.788	<.001	<.001	3	27
THCA	Antibacterial humoral response →	+0.168	+0.809	<.001	<.001	3	27

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,002 associations by consensus.

B cell receptor signaling pathway by IGHV3OR16-12 expression — CHOL

Explore this box plot interactively →