IGHV3OR16-12

Across TCGA pan-cancer cohorts, IGHV3OR16-12 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated IGHV3OR16-12 data layer compared with 7 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV3OR16-12 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGHV3OR16-12 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and UCEC are the cancer types where IGHV3OR16-12 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.757	0.613	<.001	143	view →
SKCM	DFS	Median	III,IV	0.376	0.167	<.001	106	view →
UCEC	DFS	Median	II,III,IV	0.757	0.390	.004	84	view →
BRCA	OS	Median	All	0.977	0.947	<.001	26	view →
LUAD	OS	Quartile	II,III,IV	0.825	0.505	.005	26	view →
UCS	OS	Tertile	II,III,IV	0.794	0.397	.019	24	view →
MESO	OS	Tertile	III,IV	0.730	0.472	.005	22	view →
THYM	OS	Tertile	II,III,IV	0.887	1.000	.002	17	view →
DLBC	OS	Quartile	All	0.748	0.956	.018	14	view →
CHOL	DFS	Tertile	III,IV	1.000	0.182	.034	12	view →
GBM	DFS	Tertile	All	0.116	0.263	.036	9	view →
KIRC	DFS	Median	All	0.734	0.836	.023	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

IGHV3OR16-12–HNSC (OS)

Open the HNSC breakdown →