IGHV3OR16-12

Across TCGA patient cohorts, IGHV3OR16-12 protein abundance is significantly associated with the RNA expression of many other genes, with 15,726 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGHV3OR16-12-associated genes across cancer lineages are AOC3, HLX, and DYSF. Each is linked with IGHV3OR16-12 in more than 5 cancer types. Because this analysis shows association rather than direction, both IGHV3OR16-12-to-partner and partner-to-IGHV3OR16-12 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGHV3OR16-12 versus AOC3 in OV, with a Pearson correlation of 0.46.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3OR16-12→partner) and Y-score (partner→IGHV3OR16-12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	AOC3 →	+1.158	+0.624	.001	<.001	3	6
PDAC	HLX →	+0.440	+0.751	<.001	.005	3	6
OV	DYSF →	+0.638	+0.613	.002	.001	3	5
UCEC	IRF4 →	+1.118	+0.756	.001	.006	3	5
UCEC	IGKJ5 →	+1.945	+0.607	.002	.006	3	5
OV	IGLV5-45 →	+1.935	+0.542	.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,726 associations by consensus.

IGHV3OR16-12 vs AOC3 — OV

Explore this scatter interactively →