IGHV3OR16-10

Across TCGA pan-cancer cohorts, IGHV3OR16-10 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated IGHV3OR16-10 data layer compared with 3 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV3OR16-10 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV3OR16-10 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and LIHC are the cancer types where IGHV3OR16-10 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.661	0.526	<.001	144	view →
SKCM	DFS	Tertile	III,IV	0.442	0.168	<.001	107	view →
LIHC	OS	Tertile	All	0.881	0.749	.003	90	view →
BRCA	OS	Median	All	0.978	0.947	<.001	77	view →
UVM	DFS	Tertile	All	0.327	0.762	.003	54	view →
THYM	OS	Quartile	II,III,IV	0.824	0.986	.003	42	view →
STAD	DFS	Median	All	0.598	0.712	.005	28	view →
KICH	OS	Tertile	III,IV	0.178	0.847	<.001	27	view →
LUAD	OS	Tertile	II,III,IV	0.864	0.676	.022	18	view →
OV	OS	Quartile	III,IV	0.757	0.860	.004	18	view →
CHOL	DFS	Tertile	All	0.703	0.268	.008	18	view →
GBM	OS	Tertile	All	0.249	0.421	.035	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

IGHV3OR16-10–HNSC (DFS)

Open the HNSC breakdown →