IGHV3OR16-10

Across TCGA pan-cancer cohorts, IGHV3OR16-10 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of IGHV3OR16-10’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGHV3OR16-10 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHV3OR16-10 is over-expressed in tumor, although a few such as COAD and STAD show the opposite, repressed pattern.

COAD, LUAD, and STAD are the cancer types where IGHV3OR16-10 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV3OR16-10 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−2.254	<.001	10	view →
LUAD	Male	All	+1.213	<.001	8	view →
STAD	Male	III,IV	−1.443	.019	4	view →
KIRP	Female	All	−0.174	.014	3	view →
READ	Female	All	−1.680	<.001	2	view →
LUSC	All	All	+0.605	.011	2	view →
KIRC	All	All	+0.234	.005	2	view →
BLCA	Male	IV	+0.832	.018	1	view →
HNSC	All	III,IV	+0.422	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

IGHV3OR16-10–COAD

Open the COAD breakdown →