IGHV3OR15-7

Across TCGA patient cohorts, IGHV3OR15-7 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible IGHV3OR15-7-associated genes across cancer lineages are MIR6879, PYY3, and RNA5SP188. Each is linked with IGHV3OR15-7 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV3OR15-7-to-partner and partner-to-IGHV3OR15-7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6879 grouped by IGHV3OR15-7-low versus IGHV3OR15-7-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3OR15-7→partner) and Y-score (partner→IGHV3OR15-7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MIR6879 →	+0.686	+7.930	<.001	.008	3	1
LUSC	PYY3 →	+0.130	+5.321	<.001	.002	3	1
LUSC	RNA5SP188 →	+0.230	+5.148	<.001	.002	3	1
LUSC	RNA5SP447 →	+0.337	+4.606	<.001	.006	3	1
LUSC	RNU6-899P →	+0.264	+5.517	<.001	.001	3	1
LUSC	LRRC72 →	+0.343	+4.484	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

MIR6879 by IGHV3OR15-7 expression — LUAD

Explore this box plot interactively →