IGHV3OR15-7

Across TCGA pan-cancer cohorts, IGHV3OR15-7 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated IGHV3OR15-7 data layer compared with 4 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV3OR15-7 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV3OR15-7 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, UVM, and SKCM are the cancer types where IGHV3OR15-7 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.680	0.528	<.001	144	view →
UVM	OS	Tertile	All	0.104	0.834	<.001	99	view →
SKCM	DFS	Median	All	0.675	0.560	<.001	94	view →
ACC	OS	Tertile	All	0.620	0.907	.006	66	view →
BRCA	DFS	Tertile	All	0.973	0.925	<.001	45	view →
CHOL	DFS	Median	All	0.698	0.179	<.001	36	view →
DLBC	DFS	Median	IV	0.128	1.000	.017	35	view →
UCEC	OS	Tertile	III,IV	0.743	0.463	.006	32	view →
GBM	OS	Tertile	All	0.265	0.434	.002	18	view →
COAD	DFS	Median	II,III,IV	0.862	0.685	.006	18	view →
KIRC	DFS	Median	All	0.733	0.847	.031	13	view →
STAD	OS	Median	IV	0.563	0.193	.016	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

IGHV3OR15-7–HNSC (DFS)

Open the HNSC breakdown →