IGHV3-79

Across TCGA pan-cancer cohorts, IGHV3-79 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated IGHV3-79 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV3-79 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGHV3-79 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and PAAD are the cancer types where IGHV3-79 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.843	0.680	<.001	142	view →
SKCM	OS	Median	All	0.438	0.288	<.001	90	view →
PAAD	DFS	Median	II,III,IV	0.535	0.343	<.001	83	view →
BRCA	OS	Tertile	All	0.984	0.950	<.001	56	view →
LGG	OS	Tertile	All	0.520	0.820	<.001	42	view →
KIRP	DFS	Quartile	All	0.513	0.798	<.001	38	view →
UVM	DFS	Tertile	All	0.158	0.774	.003	36	view →
THCA	DFS	Median	All	0.900	0.969	.008	20	view →
COAD	OS	Quartile	IV	0.901	0.346	.011	18	view →
ACC	OS	Tertile	IV	0.327	0.633	.045	18	view →
PRAD	OS	Quartile	All	0.805	1.000	<.001	18	view →
BLCA	DFS	Quartile	IV	0.562	0.170	.009	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

IGHV3-79–HNSC (OS)

Open the HNSC breakdown →