IGHV3-79

Across TCGA pan-cancer cohorts, IGHV3-79 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of IGHV3-79’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where IGHV3-79 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IGHV3-79 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

LUAD, KICH, and LUSC are the cancer types where IGHV3-79 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV3-79 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	II,III,IV	+1.516	<.001	9	view →
KICH	Female	All	−0.680	<.001	6	view →
LUSC	All	All	+0.391	.021	2	view →
KIRP	All	All	−0.329	.016	2	view →
PAAD	Male	All	+0.219	.036	2	view →
BRCA	Female	All	−0.157	.027	2	view →
STAD	All	IV	−1.359	.031	1	view →
COAD	Female	III,IV	−0.988	.012	1	view →
CHOL	All	All	+0.492	.012	1	view →
LIHC	Female	All	+0.196	.023	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

IGHV3-79–LUAD

Open the LUAD breakdown →