IGHV3-76

Across TCGA pan-cancer cohorts, IGHV3-76 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated IGHV3-76 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV3-76 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGHV3-76 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, UVM, and SKCM are the cancer types where IGHV3-76 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	III,IV	0.701	0.555	<.001	144	view →
UVM	DFS	Tertile	III,IV	0.120	0.747	.001	99	view →
SKCM	OS	Median	All	0.865	0.695	<.001	68	view →
CHOL	DFS	Tertile	All	0.911	0.184	<.001	56	view →
BRCA	OS	Median	All	0.976	0.948	.002	44	view →
LUAD	OS	Tertile	II,III,IV	0.783	0.496	.002	39	view →
KIRP	OS	Tertile	All	0.522	0.775	.001	38	view →
OV	DFS	Tertile	III,IV	0.448	0.349	.008	36	view →
LGG	OS	Tertile	All	0.710	0.903	<.001	33	view →
MESO	OS	Tertile	All	0.787	0.365	.008	27	view →
PRAD	DFS	Median	All	0.958	0.915	.004	20	view →
LIHC	OS	Tertile	II,III,IV	0.849	0.680	.022	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

IGHV3-76–HNSC (OS)

Open the HNSC breakdown →