IGHV3-76

Across TCGA pan-cancer cohorts, IGHV3-76 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of IGHV3-76’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGHV3-76 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHV3-76 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

COAD, LUAD, and KIRC are the cancer types where IGHV3-76 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV3-76 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−2.548	<.001	11	view →
LUAD	Female	All	+1.150	<.001	7	view →
KIRC	All	All	+0.350	.001	5	view →
BRCA	Female	II,III,IV	−0.274	.019	4	view →
READ	All	All	−1.385	.003	3	view →
LIHC	Male	All	−0.222	.011	3	view →
STAD	Male	IV	−2.710	.005	2	view →
HNSC	All	III,IV	+0.468	.037	1	view →
KICH	All	II,III,IV	−0.170	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

IGHV3-76–COAD

Open the COAD breakdown →