Across TCGA patient cohorts, IGHV3-73 mutation is significantly associated with the RNA expression of many other genes, with 67 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGHV3-73-associated genes across cancer lineages are HAUS6P1, RNA5SP414, and RNA5SP411. Each is linked with IGHV3-73 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV3-73-to-partner and partner-to-IGHV3-73 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-73→partner) and Y-score (partner→IGHV3-73) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HAUS6P1 →	+0.141	+4.004	<.001	.002	3	2
UCEC	RNA5SP414 →	+0.895	+2.933	<.001	.006	3	1
UCEC	RNA5SP411 →	+1.505	+2.715	<.001	.006	3	1
UCEC	CCDC103 →	+0.036	+4.107	.001	<.001	3	1
UCEC	LINC02563 →	+0.198	+3.420	<.001	.005	3	1
UCEC	CCDC58P3 →	+0.369	+3.796	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

Exploration

IGHV3-73 survival (RNA) · tumor vs normal (RNA) · all IGHV3-73 data types