Across TCGA pan-cancer cohorts, IGHV3-73 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated IGHV3-73 data layer compared with 1 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV3-73 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV3-73 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and LUAD are the cancer types where IGHV3-73 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.677	0.530	<.001	145	view →
SKCM	OS	Median	All	0.868	0.687	<.001	80	view →
LUAD	DFS	Median	III,IV	0.627	0.375	.001	71	view →
BRCA	OS	Quartile	All	0.673	0.530	.004	46	view →
UVM	DFS	Median	All	0.369	0.646	.005	38	view →
UCEC	DFS	Quartile	III,IV	0.848	0.664	.009	34	view →
COAD	DFS	Tertile	All	0.767	0.622	.007	27	view →
LIHC	DFS	Median	All	0.501	0.364	.003	25	view →
BLCA	DFS	Median	All	0.464	0.191	.003	24	view →
GBM	DFS	Quartile	All	0.123	0.345	.001	21	view →
READ	DFS	Median	IV	0.845	0.356	.001	16	view →
LGG	OS	Tertile	All	0.397	0.489	.014	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

Exploration

Same gene, other analysis: IGHV3-73 tumor-vs-normal RNA expression · all IGHV3-73 data types