Across TCGA patient cohorts, IGHV3-73 mutation is significantly associated with the immune_cell of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGHV3-73-associated genes across cancer lineages are Erythrocytes, Mast cells, and Th2 cells. Each is linked with IGHV3-73 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV3-73-to-partner and partner-to-IGHV3-73 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-73→partner) and Y-score (partner→IGHV3-73) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Erythrocytes →	+0.040	+2.879	.005	.033	3	1
UCEC	Mast cells →	+0.018	+3.042	.044	.018	3	1
UCEC	Th2 cells →	+0.245	+3.000	.018	.037	1	2
UCEC	Epithelial cells →	-0.087	-3.000	.035	.037	1	1
UCEC	lymphatic Endothelial cells →	-0.029	-2.946	.037	.037	1	1
UCEC	MEP →	+0.068	+3.010	<.001	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

IGHV3-73 survival (RNA) · tumor vs normal (RNA) · all IGHV3-73 data types