IGHV3-71

Across TCGA pan-cancer cohorts, IGHV3-71 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated IGHV3-71 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV3-71 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV3-71 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and KICH are the cancer types where IGHV3-71 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.756	0.636	<.001	141	view →
SKCM	OS	Median	All	0.404	0.274	<.001	116	view →
KICH	DFS	Tertile	II,III,IV	0.485	0.911	<.001	96	view →
OV	DFS	Median	All	0.434	0.330	<.001	86	view →
BRCA	DFS	Tertile	All	0.969	0.916	<.001	79	view →
LUAD	OS	Tertile	II,III,IV	0.753	0.423	<.001	61	view →
DLBC	DFS	Median	All	0.970	0.550	.006	44	view →
UCEC	OS	Median	III,IV	0.703	0.439	.008	42	view →
COAD	DFS	Median	All	0.601	0.458	.006	28	view →
KIRP	OS	Quartile	All	0.559	0.824	<.001	25	view →
GBM	OS	Tertile	All	0.177	0.435	.002	18	view →
SARC	OS	Tertile	All	0.622	0.460	.009	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

IGHV3-71–HNSC (DFS)

Open the HNSC breakdown →