IGHV3-71

Across TCGA pan-cancer cohorts, IGHV3-71 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of IGHV3-71’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGHV3-71 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHV3-71 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

COAD, LUAD, and KIRC are the cancer types where IGHV3-71 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV3-71 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−1.746	<.001	10	view →
LUAD	Male	All	+1.778	<.001	9	view →
KIRC	All	All	+0.475	<.001	4	view →
BRCA	Female	II,III,IV	−0.415	.009	4	view →
STAD	Male	IV	−4.135	.021	2	view →
CHOL	All	II,III,IV	−0.625	.037	2	view →
LIHC	Male	All	−0.473	.001	2	view →
READ	Female	All	−1.546	.018	1	view →
LUSC	All	All	+0.648	.018	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

IGHV3-71–COAD

Open the COAD breakdown →