Across TCGA patient cohorts, IGHV3-66 protein abundance is significantly associated with the RNA expression of many other genes, with 246 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible IGHV3-66-associated genes across cancer lineages are ADAM23, SLC25A2, and TNFRSF8. Each is linked with IGHV3-66 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV3-66-to-partner and partner-to-IGHV3-66 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-66→partner) and Y-score (partner→IGHV3-66) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ADAM23 →	-1.965	-1.530	.002	.001	3	1
HNSC	SLC25A2 →	+1.048	+1.380	.006	.001	3	1
HNSC	TNFRSF8 →	+0.784	+1.691	.003	.002	3	1
HNSC	ZNF211 →	+0.932	+1.216	.002	.005	3	1
HNSC	ATP6V1G1 →	+0.801	+1.405	.006	<.001	3	1
HNSC	TEX29 →	+0.833	+1.187	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 246 associations by consensus.

Exploration

IGHV3-66 survival (RNA) · tumor vs normal (RNA) · all IGHV3-66 data types