Across TCGA pan-cancer cohorts, IGHV3-66 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated IGHV3-66 data layer compared with 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV3-66 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV3-66 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and BRCA are the cancer types where IGHV3-66 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.779	0.640	<.001	139	view →
SKCM	DFS	Median	All	0.677	0.555	<.001	101	view →
BRCA	DFS	Tertile	All	0.640	0.455	<.001	82	view →
UCEC	OS	Tertile	III,IV	0.716	0.311	.002	54	view →
UVM	DFS	Tertile	II,III,IV	0.368	0.718	.006	43	view →
GBM	OS	Median	All	0.330	0.474	.001	36	view →
COAD	OS	Median	III,IV	0.893	0.671	.004	30	view →
LIHC	DFS	Median	All	0.607	0.478	.003	24	view →
SARC	OS	Tertile	All	0.913	0.778	.001	24	view →
KIRP	DFS	Quartile	All	0.440	0.913	.002	19	view →
LUAD	DFS	Quartile	IV	0.782	0.167	.024	19	view →
MESO	OS	Median	All	0.690	0.327	.019	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

Exploration

Same gene, other analysis: IGHV3-66 tumor-vs-normal RNA expression · all IGHV3-66 data types