Across TCGA patient cohorts, IGHV3-66 mutation is significantly associated with the immune_cell of many other genes, with 2 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IGHV3-66-associated genes across cancer lineages are Eosinophils and Erythrocytes. Each is linked with IGHV3-66 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV3-66-to-partner and partner-to-IGHV3-66 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-66→partner) and Y-score (partner→IGHV3-66) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Eosinophils →	+0.070	+3.731	.002	.002	3	1
SKCM	Erythrocytes →	+0.041	+3.006	<.001	.020	1	2

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

Exploration

IGHV3-66 survival (RNA) · tumor vs normal (RNA) · all IGHV3-66 data types