Across TCGA patient cohorts, IGHV3-64 mutation is significantly associated with the RNA expression of many other genes, with 88 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IGHV3-64-associated genes across cancer lineages are RN7SL815P, RNU6-718P, and LINC01591. Each is linked with IGHV3-64 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV3-64-to-partner and partner-to-IGHV3-64 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-64→partner) and Y-score (partner→IGHV3-64) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL815P →	+0.263	+5.811	<.001	<.001	3	2
SKCM	RNU6-718P →	+0.561	+2.858	<.001	.007	3	2
UCEC	LINC01591 →	+0.081	+4.262	<.001	.003	3	2
SKCM	MIR133B →	+0.772	+4.186	<.001	.007	3	2
SKCM	TSPY12P →	+0.039	+4.411	<.001	.005	3	2
UCEC	NIPA2P3 →	+0.088	+4.997	.006	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 88 associations by consensus.

Exploration

IGHV3-64 survival (RNA) · tumor vs normal (RNA) · all IGHV3-64 data types