IGHV3-62

Across TCGA pan-cancer cohorts, IGHV3-62 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated IGHV3-62 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV3-62 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV3-62 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.

HNSC, BRCA, and SKCM are the cancer types where IGHV3-62 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.399	0.261	<.001	144	view →
BRCA	OS	Tertile	All	0.618	0.516	<.001	94	view →
SKCM	OS	Median	All	0.440	0.277	<.001	75	view →
COAD	DFS	Median	III,IV	0.614	0.317	.005	42	view →
LUAD	DFS	Median	III,IV	0.666	0.316	.002	32	view →
MESO	OS	Median	All	0.739	0.285	.004	27	view →
LIHC	OS	Tertile	All	0.887	0.747	.018	26	view →
CHOL	DFS	Median	All	0.631	0.207	.002	24	view →
DLBC	DFS	Tertile	III,IV	0.070	0.855	.008	18	view →
ACC	OS	Tertile	IV	0.327	0.633	.045	18	view →
STAD	DFS	Tertile	All	0.564	0.739	.005	17	view →
PAAD	DFS	Quartile	II,III,IV	0.531	0.288	.001	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

IGHV3-62–HNSC (DFS)

Open the HNSC breakdown →