IGHV3-62

Across TCGA pan-cancer cohorts, IGHV3-62 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of IGHV3-62’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGHV3-62 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHV3-62 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

COAD, LUAD, and BRCA are the cancer types where IGHV3-62 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV3-62 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−1.360	<.001	9	view →
LUAD	Female	All	+1.391	<.001	8	view →
BRCA	Female	All	−0.334	.004	4	view →
READ	All	All	−1.448	<.001	3	view →
KIRC	Male	All	+0.404	.003	3	view →
PAAD	Female	All	−0.899	.004	2	view →
LUSC	All	All	+0.451	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

IGHV3-62–COAD

Open the COAD breakdown →