IGHV3-54

Across TCGA pan-cancer cohorts, IGHV3-54 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated IGHV3-54 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV3-54 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV3-54 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.

HNSC, UVM, and KIRP are the cancer types where IGHV3-54 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.785	0.656	<.001	128	view →
UVM	OS	Tertile	All	0.104	0.858	<.001	99	view →
KIRP	DFS	Tertile	III,IV	0.210	0.763	<.001	72	view →
BRCA	OS	Tertile	All	0.983	0.953	<.001	67	view →
DLBC	OS	Tertile	II,III,IV	0.085	0.865	<.001	54	view →
PAAD	OS	Median	II,III,IV	0.698	0.493	<.001	45	view →
OV	OS	Tertile	IV	0.028	0.759	.002	36	view →
LGG	DFS	Tertile	All	0.160	0.828	<.001	36	view →
CHOL	DFS	Tertile	All	0.819	0.282	.018	21	view →
UCS	OS	Tertile	III,IV	0.221	0.600	.049	18	view →
SKCM	DFS	Tertile	All	0.760	0.586	.020	15	view →
MESO	OS	Tertile	III,IV	0.803	0.500	.007	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

IGHV3-54–HNSC (DFS)

Open the HNSC breakdown →