IGHV3-54

Across TCGA pan-cancer cohorts, IGHV3-54 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of IGHV3-54’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGHV3-54 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHV3-54 is over-expressed in tumor, although a few such as COAD and STAD show the opposite, repressed pattern.

COAD, LUAD, and STAD are the cancer types where IGHV3-54 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV3-54 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	−0.855	<.001	11	view →
LUAD	All	All	+0.493	<.001	7	view →
STAD	All	IV	−1.266	.001	6	view →
BRCA	Female	All	−0.116	.007	6	view →
READ	All	All	−0.943	.001	5	view →
LIHC	Male	All	−0.066	.009	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

IGHV3-54–COAD

Open the COAD breakdown →