IGHV3-52

Across TCGA pan-cancer cohorts, IGHV3-52 Mutation is linked to patient survival in 1 of 34 cancer types, making it a survival-associated IGHV3-52 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV3-52 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGHV3-52 expression acts as an unfavorable survival marker.

HNSC are the cancer types where IGHV3-52 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.101	0.710	<.001	24	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

IGHV3-52–HNSC (DFS)

Open the HNSC breakdown →