IGHV3-43

Across TCGA patient cohorts, IGHV3-43 protein abundance is significantly associated with the RNA expression of many other genes, with 8,192 significant associations in total. OV shows the largest number of these associations.

The most reproducible IGHV3-43-associated genes across cancer lineages are ENPP2, LAX1, and IGHV1-58. Each is linked with IGHV3-43 in more than 4 cancer types. Because this analysis shows association rather than direction, both IGHV3-43-to-partner and partner-to-IGHV3-43 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGHV3-43 versus ENPP2 in GBM, with a Pearson correlation of 0.41.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-43→partner) and Y-score (partner→IGHV3-43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ENPP2 →	+1.837	+0.815	<.001	<.001	3	5
UCEC	LAX1 →	+0.919	+0.654	.008	.001	3	4
HNSC	IGHV1-58 →	+2.028	+0.519	.001	.005	3	4
OV	LINC02362 →	+1.080	+1.183	.006	<.001	3	4
LUAD	IGHV3OR16-9 →	+1.498	+0.701	<.001	<.001	3	4
LUAD	FCRLA →	+0.907	+0.648	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,192 associations by consensus.

IGHV3-43 vs ENPP2 — GBM

Explore this scatter interactively →