IGHV3-43

Across TCGA pan-cancer cohorts, IGHV3-43 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated IGHV3-43 data layer compared with 4 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV3-43 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV3-43 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and BRCA are the cancer types where IGHV3-43 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.452	0.278	<.001	142	view →
SKCM	DFS	Tertile	All	0.686	0.539	<.001	110	view →
BRCA	DFS	Quartile	All	0.967	0.917	.003	40	view →
UCEC	DFS	Tertile	III,IV	0.639	0.416	.017	34	view →
SARC	OS	Median	All	0.612	0.386	.004	23	view →
KIRP	OS	Median	All	0.582	0.889	.003	22	view →
UVM	DFS	Tertile	All	0.575	0.797	.029	18	view →
OV	DFS	Median	II,III,IV	0.419	0.341	.009	16	view →
CESC	OS	Median	All	0.863	0.730	.002	14	view →
LUAD	OS	Median	II,III,IV	0.707	0.482	.005	13	view →
MESO	OS	Quartile	III,IV	0.793	0.131	.017	12	view →
COAD	DFS	Median	III,IV	0.731	0.475	.009	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

IGHV3-43–HNSC (DFS)

Open the HNSC breakdown →