IGHV3-43

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, IGHV3-43 protein abundance is significantly associated with the protein abundance of many other proteins, with 11,132 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IGHV3-43-associated proteins across cancer lineages are IGHV2-5, IGHG1, and IGHV4-28. Each is linked with IGHV3-43 in more than 9 cancer types. Because this analysis shows association rather than direction, both IGHV3-43-to-partner and partner-to-IGHV3-43 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGHV3-43 versus IGHV2-5 in GBM, with a Pearson correlation of 0.49.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-43→partner) and Y-score (partner→IGHV3-43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMIGHV2-5 →+0.926+0.823<.001<.001310
OVIGHG1 →+0.829+0.942<.001<.00139
OVIGHV4-28 →+1.045+0.987<.001<.00139
OVIGHV5-51 →+0.844+0.890<.001<.00139
BRCAIGKV4-1 →+1.005+0.706<.001<.00139
OVIGLL5 →+0.830+0.878<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest of 11,132 associations by consensus.

IGHV3-43 vs IGHV2-5 — GBM

Per-sample scatter of IGHV3-43 vs IGHV2-5 in GBM (Pearson r = 0.49).

Explore this scatter interactively →

Exploration