IGHV3-43

Across TCGA patient cohorts, IGHV3-43 mutation is significantly associated with the RNA expression of many other genes, with 169 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IGHV3-43-associated genes across cancer lineages are TMEM179B, WWP2, and IL26. Each is linked with IGHV3-43 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV3-43-to-partner and partner-to-IGHV3-43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM179B grouped by IGHV3-43-low versus IGHV3-43-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-43→partner) and Y-score (partner→IGHV3-43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TMEM179B →	+0.519	+3.370	.002	.004	3	2
SKCM	WWP2 →	+0.743	+3.246	<.001	.008	3	2
UCEC	IL26 →	+0.245	+4.308	<.001	<.001	3	1
UCEC	ZIC5 →	+1.570	+3.600	<.001	.004	3	1
SKCM	RNU6-377P →	+0.400	+2.418	.002	.004	3	1
SKCM	LINC02420 →	+0.034	+2.647	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 169 associations by consensus.

TMEM179B by IGHV3-43 expression — SKCM

Explore this box plot interactively →