IGHV3-43

Across TCGA patient cohorts, IGHV3-43 mutation is significantly associated with the immune_cell of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGHV3-43-associated genes across cancer lineages are Fibroblasts, CD8+ T-cells, and Megakaryocytes. Each is linked with IGHV3-43 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV3-43-to-partner and partner-to-IGHV3-43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fibroblasts grouped by IGHV3-43-low versus IGHV3-43-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-43→partner) and Y-score (partner→IGHV3-43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Fibroblasts →	+0.007	+3.338	<.001	.019	3	1
UCEC	CD8+ T-cells →	+0.018	+3.523	.009	.001	3	1
UCEC	Megakaryocytes →	-0.034	-2.975	.015	.036	3	1
UCEC	CD4+ memory T-cells →	+0.024	+1.939	.019	.044	3	1
UCEC	Th1 cells →	+0.115	+3.000	.033	.037	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Fibroblasts by IGHV3-43 expression — SKCM

Explore this box plot interactively →