IGHV3-41

Across TCGA patient cohorts, IGHV3-41 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,110 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IGHV3-41-associated GO terms across cancer lineages are Positive regulation of respiratory burst, Complement activation, and B cell receptor signaling pathway. Each is linked with IGHV3-41 in more than 28 cancer types. Because this analysis shows association rather than direction, both IGHV3-41-to-partner and partner-to-IGHV3-41 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of respiratory burst grouped by IGHV3-41-low versus IGHV3-41-high in CHOL.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-41→partner) and Y-score (partner→IGHV3-41) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	Positive regulation of respiratory burst →	+0.175	+1.144	<.001	<.001	3	29
THCA	Complement activation →	+0.156	+1.379	<.001	<.001	3	29
CHOL	B cell receptor signaling pathway →	+0.104	+1.401	<.001	.001	3	29
CHOL	Respiratory burst →	+0.094	+1.454	<.001	<.001	3	29
SKCM	Positive regulation of leukocyte cell-cell adhesion →	+0.049	+0.921	<.001	<.001	3	28
CHOL	Regulation of T cell apoptotic process →	+0.072	+1.560	<.001	.006	3	28

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,110 associations by consensus.

Positive regulation of respiratory burst by IGHV3-41 expression — CHOL

Explore this box plot interactively →