IGHV3-41

Across TCGA pan-cancer cohorts, IGHV3-41 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated IGHV3-41 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV3-41 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV3-41 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, UCEC, and BRCA are the cancer types where IGHV3-41 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.767	0.622	<.001	142	view →
UCEC	OS	Median	II,III,IV	0.722	0.282	<.001	92	view →
BRCA	DFS	Tertile	All	0.580	0.496	.004	63	view →
SKCM	OS	Median	All	0.863	0.686	<.001	59	view →
LUAD	OS	Median	II,III,IV	0.841	0.656	.004	41	view →
GBM	OS	Tertile	All	0.044	0.431	<.001	36	view →
OV	DFS	Median	All	0.426	0.348	.009	22	view →
STAD	DFS	Quartile	All	0.547	0.752	.008	20	view →
CHOL	DFS	Tertile	All	0.763	0.278	.005	18	view →
UCS	DFS	Quartile	II,III,IV	0.769	0.342	.006	18	view →
LGG	OS	Tertile	All	0.358	0.451	.021	12	view →
LUSC	DFS	Tertile	II,III,IV	0.304	0.528	.007	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

IGHV3-41–HNSC (DFS)

Open the HNSC breakdown →