IGHV3-37

Across TCGA pan-cancer cohorts, IGHV3-37 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated IGHV3-37 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV3-37 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV3-37 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, UVM, and READ are the cancer types where IGHV3-37 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.752	0.639	<.001	141	view →
UVM	OS	Tertile	All	0.222	0.876	<.001	108	view →
READ	OS	Quartile	III,IV	0.476	0.830	<.001	41	view →
UCEC	DFS	Quartile	III,IV	0.742	0.489	.014	34	view →
SKCM	DFS	Quartile	III,IV	0.625	0.200	.002	32	view →
LUAD	DFS	Tertile	II,III,IV	0.697	0.447	.014	32	view →
CHOL	DFS	Quartile	All	0.791	0.214	.005	24	view →
BRCA	OS	Median	All	0.976	0.948	<.001	23	view →
STAD	DFS	Quartile	All	0.603	0.727	.009	21	view →
ESCA	OS	Median	III,IV	0.542	0.331	.021	15	view →
COAD	DFS	Tertile	All	0.766	0.633	.006	12	view →
LIHC	DFS	Tertile	III,IV	1.000	0.293	.030	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

IGHV3-37–HNSC (DFS)

Open the HNSC breakdown →