IGHV3-37

Across TCGA pan-cancer cohorts, IGHV3-37 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of IGHV3-37’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGHV3-37 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHV3-37 is over-expressed in tumor, although a few such as COAD and STAD show the opposite, repressed pattern.

COAD, LUAD, and STAD are the cancer types where IGHV3-37 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV3-37 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	−0.977	<.001	9	view →
LUAD	Male	All	+0.790	<.001	8	view →
STAD	Male	IV	−2.360	.005	5	view →
READ	All	All	−1.106	.001	5	view →
KIRC	Male	All	+0.254	.002	5	view →
BRCA	Female	All	−0.225	.001	4	view →
LIHC	Male	All	−0.097	.034	2	view →
BLCA	Male	III,IV	+0.295	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

IGHV3-37–COAD

Open the COAD breakdown →