IGHV3-36

Across TCGA patient cohorts, IGHV3-36 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,758 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IGHV3-36-associated GO terms across cancer lineages are B cell receptor signaling pathway, B cell mediated immunity, and Immunoglobulin production. Each is linked with IGHV3-36 in more than 26 cancer types. Because this analysis shows association rather than direction, both IGHV3-36-to-partner and partner-to-IGHV3-36 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, B cell receptor signaling pathway grouped by IGHV3-36-low versus IGHV3-36-high in SARC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-36→partner) and Y-score (partner→IGHV3-36) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SARC	B cell receptor signaling pathway →	+0.085	+0.134	<.001	<.001	3	27
THCA	B cell mediated immunity →	+0.100	+0.447	<.001	<.001	3	25
STAD	Immunoglobulin production →	+0.079	+0.374	<.001	<.001	3	25
SARC	Antigen receptor-mediated signaling pathway →	+0.065	+0.139	<.001	<.001	3	25
THYM	Negative regulation of T cell apoptotic process →	+0.074	+0.416	<.001	<.001	3	24
LAML	Positive T cell selection →	+0.067	+0.438	<.001	<.001	3	24

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,758 associations by consensus.

B cell receptor signaling pathway by IGHV3-36 expression — SARC

Explore this box plot interactively →