IGHV3-36

Across TCGA pan-cancer cohorts, IGHV3-36 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated IGHV3-36 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV3-36 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV3-36 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BLCA show a favorable association.

HNSC, UVM, and BLCA are the cancer types where IGHV3-36 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.757	0.645	<.001	132	view →
UVM	OS	Tertile	II,III,IV	0.259	0.734	<.001	108	view →
BLCA	DFS	Quartile	All	0.633	0.206	.002	58	view →
CESC	DFS	Median	All	0.831	0.682	.002	28	view →
STAD	DFS	Quartile	All	0.537	0.692	.003	25	view →
READ	DFS	Median	All	0.884	0.398	.007	25	view →
BRCA	OS	Median	II,III,IV	0.974	0.944	.010	23	view →
KIRP	DFS	Tertile	All	0.552	0.826	.023	18	view →
LUAD	DFS	Tertile	II,III,IV	0.810	0.610	.018	14	view →
MESO	OS	Tertile	III,IV	0.821	0.502	.008	12	view →
OV	OS	Tertile	All	0.799	0.848	.022	12	view →
PAAD	OS	Tertile	II,III,IV	0.680	0.444	.007	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

IGHV3-36–HNSC (DFS)

Open the HNSC breakdown →