Across TCGA pan-cancer cohorts, IGHV3-35 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of IGHV3-35’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where IGHV3-35 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types IGHV3-35 is over-expressed in tumor, although a few such as HNSC and COAD show the opposite, repressed pattern.
HNSC, COAD, and LUAD are the cancer types where IGHV3-35 tumor–normal differential expression is most reproducible.
mass-spec protein tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV3-35 mass-spec protein (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.