IGHV3-33-2

Across TCGA patient cohorts, IGHV3-33-2 RNA expression is significantly associated with the protein abundance of many other proteins, with 6,713 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGHV3-33-2-associated proteins across cancer lineages are EVL_S246, IL16, and LCP1. Each is linked with IGHV3-33-2 in more than 3 cancer types. Because this analysis shows association rather than direction, both IGHV3-33-2-to-partner and partner-to-IGHV3-33-2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGHV3-33-2 versus EVL_S246 in HNSC, with a Pearson correlation of 0.28.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-33-2→partner) and Y-score (partner→IGHV3-33-2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	EVL_S246 →	+0.639	+0.433	<.001	.004	3	4
UCEC	IL16 →	+0.461	+0.267	<.001	.001	3	4
UCEC	LCP1 →	+0.536	+0.257	<.001	.001	3	4
UCEC	LIMD2 →	+0.439	+0.224	.001	.006	3	4
HNSC	PTPN6 →	+0.403	+0.519	<.001	<.001	3	3
UCEC	NADK →	+0.301	+0.176	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,713 associations by consensus.

IGHV3-33-2 vs EVL_S246 — HNSC

Explore this scatter interactively →