IGHV3-33-2

Across TCGA pan-cancer cohorts, IGHV3-33-2 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated IGHV3-33-2 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV3-33-2 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV3-33-2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.

HNSC, UVM, and BRCA are the cancer types where IGHV3-33-2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	IV	0.497	0.285	.001	111	view →
UVM	OS	Tertile	All	0.037	0.835	<.001	54	view →
BRCA	OS	Tertile	All	0.957	0.911	.009	47	view →
SKCM	DFS	Median	All	0.699	0.569	<.001	45	view →
KIRC	OS	Tertile	All	0.546	0.651	.007	30	view →
PAAD	OS	Quartile	II,III,IV	0.806	0.434	<.001	29	view →
THYM	DFS	Tertile	III,IV	0.463	0.894	.014	21	view →
CESC	OS	Tertile	All	0.946	0.843	.012	20	view →
ESCA	DFS	Tertile	II,III,IV	0.488	0.252	.022	15	view →
GBM	DFS	Tertile	All	0.068	0.288	.003	9	view →
OV	OS	Tertile	All	0.779	0.847	.033	6	view →
LUAD	DFS	Median	All	0.482	0.278	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

IGHV3-33-2–HNSC (DFS)

Open the HNSC breakdown →