IGHV3-30-2

Across TCGA patient cohorts, IGHV3-30-2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,718 significant associations in total. STAD shows the largest number of these associations.

The most reproducible IGHV3-30-2-associated GO terms across cancer lineages are B cell receptor signaling pathway, Regulation of B cell activation, and Regulation of leukocyte proliferation. Each is linked with IGHV3-30-2 in more than 19 cancer types. Because this analysis shows association rather than direction, both IGHV3-30-2-to-partner and partner-to-IGHV3-30-2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, B cell receptor signaling pathway grouped by IGHV3-30-2-low versus IGHV3-30-2-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-30-2→partner) and Y-score (partner→IGHV3-30-2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	B cell receptor signaling pathway →	+0.101	+0.134	<.001	<.001	3	20
STAD	Regulation of B cell activation →	+0.072	+0.130	<.001	<.001	3	19
STAD	Regulation of leukocyte proliferation →	+0.065	+0.125	<.001	<.001	3	19
STAD	B cell activation →	+0.076	+0.131	<.001	<.001	3	19
THCA	Positive T cell selection →	+0.078	+0.047	<.001	<.001	3	19
STAD	T cell selection →	+0.079	+0.140	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,718 associations by consensus.

B cell receptor signaling pathway by IGHV3-30-2 expression — STAD

Explore this box plot interactively →