IGHV3-30-2

Across TCGA pan-cancer cohorts, IGHV3-30-2 RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated IGHV3-30-2 data layer.

The strongest signal is observed in thyroid carcinoma (THCA), where higher IGHV3-30-2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IGHV3-30-2 expression acts as an unfavorable survival marker, although some lineages such as COAD and LUAD show a favorable association.

THCA, COAD, and LUAD are the cancer types where IGHV3-30-2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	OS	Tertile	IV	0.292	0.953	<.001	48	view →
COAD	OS	Tertile	III,IV	1.000	0.748	.021	24	view →
LUAD	DFS	Tertile	III,IV	0.844	0.563	.012	24	view →
CESC	OS	Tertile	IV	0.095	0.592	.004	18	view →
LIHC	OS	Tertile	II,III,IV	0.402	0.701	.002	18	view →
UCS	DFS	Tertile	All	0.136	0.523	.034	18	view →
DLBC	DFS	Tertile	II,III,IV	0.557	0.882	.010	14	view →
CHOL	DFS	Tertile	All	1.000	0.329	.020	9	view →
SKCM	DFS	Tertile	All	0.458	0.189	.042	6	view →
LUSC	DFS	Tertile	All	0.234	0.414	.022	6	view →
THYM	OS	Median	All	1.000	0.691	.018	5	view →
HNSC	DFS	Tertile	II,III,IV	0.671	0.277	.029	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

IGHV3-30-2–THCA (OS)

Open the THCA breakdown →