IGHV3-23

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, IGHV3-23 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGHV3-23-associated genes across cancer lineages are ASNS, EGFR, and ACC_pS79. Each is linked with IGHV3-23 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV3-23-to-partner and partner-to-IGHV3-23 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-23→partner) and Y-score (partner→IGHV3-23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECASNS →+0.657+3.000.001.03732
UCECEGFR →-0.212-3.000.022.03731
UCECACC_pS79 →+0.408+3.000.041.03731
UCECACC1 →+0.443+3.000.035.03722
UCECPDCD4 →-0.619-3.000.022.03731
UCECSTAT3_pY705 →-0.615-2.999<.001.03531
Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Exploration