Across TCGA pan-cancer cohorts, IGHV3-23 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated IGHV3-23 data layer compared with 4 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV3-23 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV3-23 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and UVM are the cancer types where IGHV3-23 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.764	0.626	<.001	144	view →
SKCM	OS	Median	All	0.405	0.275	<.001	116	view →
UVM	DFS	Median	All	0.576	0.879	.004	67	view →
BRCA	DFS	Median	All	0.970	0.926	<.001	65	view →
UCEC	OS	Tertile	III,IV	0.694	0.363	.003	54	view →
LUAD	OS	Median	II,III,IV	0.591	0.323	<.001	42	view →
LIHC	DFS	Median	All	0.604	0.478	.003	41	view →
COAD	DFS	Median	II,III,IV	0.743	0.594	.001	41	view →
KIRP	DFS	Quartile	II,III,IV	0.556	0.873	.008	33	view →
SARC	OS	Tertile	All	0.646	0.418	<.001	33	view →
CHOL	DFS	Tertile	All	0.717	0.215	.002	18	view →
KIRC	DFS	Tertile	All	0.471	0.704	.010	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

Exploration

Same gene, other analysis: IGHV3-23 tumor-vs-normal RNA expression · all IGHV3-23 data types