Across TCGA patient cohorts, IGHV3-21 RNA expression is significantly associated with the RNA expression of many other genes, with 10,176 significant associations in total. PAAD shows the largest number of these associations.

The most reproducible IGHV3-21-associated genes across cancer lineages are IGHV3-23, IGHV1-24, and IGHV4-28. Each is linked with IGHV3-21 in more than 32 cancer types. Because this analysis shows association rather than direction, both IGHV3-21-to-partner and partner-to-IGHV3-21 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-21→partner) and Y-score (partner→IGHV3-21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	IGHV3-23 →	+5.843	+5.121	<.001	<.001	3	33
THCA	IGHV1-24 →	+4.481	+4.930	<.001	<.001	3	33
THCA	IGHV4-28 →	+3.466	+5.024	<.001	<.001	3	33
THCA	IGHV3-33 →	+4.811	+4.980	<.001	<.001	3	33
THCA	IGHV4-34 →	+4.993	+5.007	<.001	<.001	3	33
LUSC	IGHV3-35 →	+2.081	+3.018	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,176 associations by consensus.

Exploration

IGHV3-21 survival (RNA) · tumor vs normal (RNA) · all IGHV3-21 data types