IGHV3-21

RNA expression — cross-omics
Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, IGHV3-21 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,422 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGHV3-21-associated proteins across cancer lineages are MZB1, IL16, and INPP5D. Each is linked with IGHV3-21 in more than 9 cancer types. Because this analysis shows association rather than direction, both IGHV3-21-to-partner and partner-to-IGHV3-21 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-21→partner) and Y-score (partner→IGHV3-21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OVMZB1 →+1.688+4.641<.001<.001310
OVIL16 →+0.676+4.231<.001<.001310
OVINPP5D →+0.567+4.041.002<.00139
BRCAISG20 →+0.867+2.845<.001<.00139
GBMLSP1 →+0.809+1.745<.001<.00139
LSCCARHGAP45 →+0.457+1.271<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest of 14,422 associations by consensus.

Exploration