IGHV3-20

RNA expression — cross-omics
Cross-omicsRNA → MUTATIONPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, IGHV3-20 RNA expression is significantly associated with the mutation status of many other genes, with 8,894 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGHV3-20-associated genes across cancer lineages are KRAS, KIR3DX1, and AFF2. Each is linked with IGHV3-20 in more than 4 cancer types. Because this analysis shows association rather than direction, both IGHV3-20-to-partner and partner-to-IGHV3-20 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-20→partner) and Y-score (partner→IGHV3-20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
READKRAS →-1.027-0.712.002.00835
UCECKIR3DX1 →+2.459+1.315<.001<.00133
UCECAFF2 →+1.148+0.940<.001<.00133
UCECABCC2 →+1.882+0.916<.001<.00133
UCECTRPC5 →+1.544+1.014<.001<.00133
UCECDSP →+1.222+0.957<.001<.00133
Each partner links to its Q-omics profile. Showing the 6 strongest of 8,894 associations by consensus.

Exploration