Across TCGA patient cohorts, IGHV3-20 mutation is significantly associated with the RNA expression of many other genes, with 48 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IGHV3-20-associated genes across cancer lineages are RNU6-160P, MTCYBP45, and NXPE2P1. Each is linked with IGHV3-20 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV3-20-to-partner and partner-to-IGHV3-20 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-20→partner) and Y-score (partner→IGHV3-20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-160P →	+0.392	+5.392	<.001	.002	3	1
COAD	MTCYBP45 →	+0.353	+6.734	<.001	<.001	3	1
COAD	NXPE2P1 →	+0.299	+4.181	<.001	.009	3	1
SKCM	FAM96AP1 →	+0.075	+5.212	<.001	.002	3	1
SKCM	UBTFL2 →	+0.036	+4.884	<.001	.004	3	1
SKCM	OR7E46P →	+0.048	+3.953	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

Exploration

IGHV3-20 survival (RNA) · tumor vs normal (RNA) · all IGHV3-20 data types