Across TCGA patient cohorts, IGHV3-16 mutation is significantly associated with the RNA expression of many other genes, with 166 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGHV3-16-associated genes across cancer lineages are MIR7976, FANCD2P2, and LINC01850. Each is linked with IGHV3-16 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV3-16-to-partner and partner-to-IGHV3-16 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-16→partner) and Y-score (partner→IGHV3-16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR7976 →	+0.513	+4.043	<.001	<.001	3	2
SKCM	FANCD2P2 →	+0.213	+3.253	<.001	.001	3	2
UCEC	LINC01850 →	+0.251	+2.671	<.001	.005	3	2
UCEC	CHCHD2P3 →	+0.207	+2.603	<.001	.007	3	1
UCEC	MIR6514 →	+0.919	+3.667	.002	.003	3	1
UCEC	MIR1273H →	+0.313	+3.399	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 166 associations by consensus.

Exploration

IGHV3-16 survival (RNA) · tumor vs normal (RNA) · all IGHV3-16 data types