Across TCGA patient cohorts, IGHV3-15 mutation is significantly associated with the RNA expression of many other genes, with 92 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IGHV3-15-associated genes across cancer lineages are MIR190B, TRAJ52, and RPSAP50. Each is linked with IGHV3-15 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV3-15-to-partner and partner-to-IGHV3-15 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-15→partner) and Y-score (partner→IGHV3-15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR190B →	+0.158	+3.356	<.001	.005	3	2
COAD	TRAJ52 →	+1.284	+4.754	<.001	.003	3	1
COAD	RPSAP50 →	+0.165	+4.237	.006	.008	3	1
COAD	IGLVIV-66-1 →	+0.162	+4.516	<.001	.009	3	1
COAD	MIR3922 →	+0.891	+5.392	<.001	.002	3	1
COAD	MIR3135A →	+0.587	+4.602	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 92 associations by consensus.

Exploration

IGHV3-15 survival (RNA) · tumor vs normal (RNA) · all IGHV3-15 data types