Across TCGA patient cohorts, IGHV3-13 mutation is significantly associated with the RNA expression of many other genes, with 74 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGHV3-13-associated genes across cancer lineages are SNRPGP17, MIR2909, and MIR6780B. Each is linked with IGHV3-13 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV3-13-to-partner and partner-to-IGHV3-13 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-13→partner) and Y-score (partner→IGHV3-13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNRPGP17 →	+0.389	+3.200	.002	.005	3	2
SKCM	MIR2909 →	+0.239	+3.159	<.001	.008	3	1
UCEC	MIR6780B →	+0.556	+3.474	<.001	.006	3	1
LUAD	KRTAP9-8 →	+0.164	+7.930	<.001	.008	3	1
LUAD	SNORD115-42 →	+0.728	+7.930	<.001	.008	3	1
LUAD	RNU6-200P →	+0.292	+7.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 74 associations by consensus.

Exploration

IGHV3-13 survival (RNA) · tumor vs normal (RNA) · all IGHV3-13 data types